HMM Summary Page: TIGR00705

Functionsignal peptide peptidase SppA, 67K type
Gene SymbolsppA
Trusted Cutoff311.45
Domain Trusted Cutoff311.45
Noise Cutoff229.00
Domain Noise Cutoff229.00
Isology Typeequivalog
EC Number3.4.-.-
HMM Length590
Mainrole CategoryProtein fate
Subrole CategoryDegradation of proteins, peptides, and glycopeptides
Gene Ontology TermGO:0006508: proteolysis biological_process
AuthorHaft DH
Entry DateFeb 1 2000 10:52AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents the signal peptide peptidase A (SppA, protease IV) as found in E. coli, Treponema pallidum, Mycobacterium leprae, and several other species, in which it has a molecular mass around 67 kDa and a duplication such that the N-terminal half shares extensive homology with the C-terminal half. This enzyme was shown in E. coli to form homotetramers. E. coli SohB, which is most closely homologous to the C-terminal duplication of SppA, is predicted to perform a similar function of small peptide degradation, but in the periplasm. Many prokaryotes have a single SppA/SohB homolog that may perform the function of either or both.
ReferencesA2 hmmalign AL clustalw DR EXPERIMENTAL; EGAD|20229|EC1766 RN [1] RM 87222172 RT Characterization of the sppA gene coding for protease IV, a signal peptide peptidase of Escherichia coli. RA Suzuki T, Itoh A, Ichihara S, Mizushima S RL J Bacteriol 1987 Jun;169(6):2523-8
Genome PropertyGenProp0205: signal recognition system, bacterial (HMM)