HMM Summary Page: TIGR00702

FunctionYcaO-type kinase domain
Trusted Cutoff75.65
Domain Trusted Cutoff75.65
Noise Cutoff41.35
Domain Noise Cutoff41.35
Isology Typedomain
HMM Length377
Mainrole CategoryHypothetical proteins
Subrole CategoryConserved
AuthorHaft DH
Entry DateFeb 1 2000 10:52AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis protein family includes YcaO and homologs that can phosphorylate a peptide amide backbone (rather than side chains), as during heterocycle-forming modifications during maturation of the TOMM class (Thiazole/Oxazole-Modified Microcins) of bacteriocins. However, YcaO domain proteins also occur in contexts that do not suggest peptide modification.
ReferencesRN [1] RM PMID:22522320 RT YcaO domains use ATP to activate amide backbones during peptide cyclodehydrations. RA Dunbar KL, Melby JO, Mitchell DA RL Nat Chem Biol. 2012 Apr 22;8(6):569-75. DR InterPro; IPR003776 DR PFAM; PF02624