HMM Summary Page: TIGR00700

Function4-aminobutyrate transaminase
Gene SymbolgabT
Trusted Cutoff506.65
Domain Trusted Cutoff506.65
Noise Cutoff317.80
Domain Noise Cutoff317.80
Isology Typeequivalog
EC Number2.6.1.19
HMM Length420
Mainrole CategoryCentral intermediary metabolism
Subrole CategoryOther
Gene Ontology TermGO:0003867: 4-aminobutyrate transaminase activity molecular_function
GO:0009450: gamma-aminobutyric acid catabolic process biological_process
AuthorHaft DH
Entry DateFeb 1 2000 10:52AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis enzyme is a class III pyridoxal-phosphate-dependent aminotransferase. This model describes known bacterial examples of the enzyme. The best archaeal matches are presumed but not trusted to have the equivalent function. The degree of sequence difference between this set and known eukaryotic (mitochondrial) examples is greater than the distance to some proteins known to have different functions, and so separate models are built for prokaryotic and eukaryotic sets. E. coli has two isozymes. Alternate names include GABA transaminase, gamma-amino-N-butyrate transaminase, and beta-alanine--oxoglutarate aminotransferase.
ReferencesA2 hmmalign AL clustalw DR PROSITE; PDOC00519; Aminotransferases class-III pyridoxal-phosphate attachment site DR PFAM; PF00202; Aminotransferases class-III pyridoxal-phosphate
Genome PropertyGenProp0233: GABA utilization (HMM)