HMM Summary Page: TIGR00693

Functionthiamine-phosphate diphosphorylase
Gene SymbolthiE
Trusted Cutoff145.10
Domain Trusted Cutoff145.10
Noise Cutoff60.35
Domain Noise Cutoff60.35
Isology Typeequivalog_domain
EC Number2.5.1.3
HMM Length197
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryThiamine
Gene Ontology TermGO:0004789: thiamine-phosphate diphosphorylase activity molecular_function
GO:0009228: thiamine biosynthetic process biological_process
AuthorLoftus BJ, Haft DH
Entry DateJan 13 2000 2:41PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents the thiamine-phosphate pyrophosphorylase, ThiE, of a number of bacteria, and N-terminal domains of bifunctional thiamine proteins of Saccharomyces cerevisiae and Schizosaccharomyces pombe, in which the C-terminal domain corresponds to the bacterial hydroxyethylthiazole kinase (EC, ThiM. This model includes ThiE from Bacillus subtilis but excludes its paralog, the regulatory protein TenI (SP:P25053), and neighbors of TenI.
ReferencesDR SWISSPROT; P30137 DR ECOCYC; EG11586; thiE RM 98363648 DR EXPERIMENTAL; GP|2746079|gb|AAC31298.1||AF015310; Brassica napus DR EXPERIMENTAL; EGAD|56426|YPL214C; Saccharomyces cerevisiae DR EXPERIMENTAL; EGAD|10927|EC3993; Escherichia coli DR HAMAP; MF_01327; 11 of 11
Genome PropertyGenProp0254: thiamine: TPP from HMP-PP and HET-P (HMM)