Accession | TIGR00692 |
Name | tdh |
Function | L-threonine 3-dehydrogenase |
Gene Symbol | tdh |
Trusted Cutoff | 458.35 |
Domain Trusted Cutoff | 458.35 |
Noise Cutoff | 348.75 |
Domain Noise Cutoff | 348.75 |
Isology Type | equivalog |
EC Number | 1.1.1.103 |
HMM Length | 340 |
Mainrole Category | Energy metabolism |
Subrole Category | Amino acids and amines |
Gene Ontology Term | GO:0006567: threonine catabolic process biological_process |
| GO:0008743: L-threonine 3-dehydrogenase activity molecular_function |
Author | Haft DH |
Entry Date | Jan 13 2000 2:41PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | This protein is a tetrameric, zinc-binding, NAD-dependent enzyme of threonine catabolism. Closely related proteins include sorbitol dehydrogenase, xylitol dehydrogenase, and benzyl alcohol dehydrogenase. Eukaryotic examples of this enzyme have been demonstrated experimentally but do not appear in database search results.
E. coli His-90 modulates substrate specificity and is believed part of the active site.
|
References | AL clustalw
RN [1]
RM 98162635
RT Site-directed mutagenesis of histidine-90 in Escherichia coli L-threonine dehydrogenase alters its substrate specificity.
RA Johnson AR, Dekker EE
RL Arch Biochem Biophys 1998 Mar 1;351(1):8-16
DR EXPERIMENTAL; EGAD|143282|152806; Xanthomonas campestris
DR EXPERIMENTAL; EGAD|7118|EC3616; Escherichia coli
DR ECOCYC; EG10993; tdh
DR HAMAP; MF_00627; 117 of 127 |