HMM Summary Page: TIGR00692

FunctionL-threonine 3-dehydrogenase
Gene Symboltdh
Trusted Cutoff458.35
Domain Trusted Cutoff458.35
Noise Cutoff348.75
Domain Noise Cutoff348.75
Isology Typeequivalog
EC Number1.1.1.103
HMM Length340
Mainrole CategoryEnergy metabolism
Subrole CategoryAmino acids and amines
Gene Ontology TermGO:0006567: threonine catabolic process biological_process
GO:0008743: L-threonine 3-dehydrogenase activity molecular_function
AuthorHaft DH
Entry DateJan 13 2000 2:41PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis protein is a tetrameric, zinc-binding, NAD-dependent enzyme of threonine catabolism. Closely related proteins include sorbitol dehydrogenase, xylitol dehydrogenase, and benzyl alcohol dehydrogenase. Eukaryotic examples of this enzyme have been demonstrated experimentally but do not appear in database search results. E. coli His-90 modulates substrate specificity and is believed part of the active site.
ReferencesAL clustalw RN [1] RM 98162635 RT Site-directed mutagenesis of histidine-90 in Escherichia coli L-threonine dehydrogenase alters its substrate specificity. RA Johnson AR, Dekker EE RL Arch Biochem Biophys 1998 Mar 1;351(1):8-16 DR EXPERIMENTAL; EGAD|143282|152806; Xanthomonas campestris DR EXPERIMENTAL; EGAD|7118|EC3616; Escherichia coli DR ECOCYC; EG10993; tdh DR HAMAP; MF_00627; 117 of 127