HMM Summary Page: TIGR00691

FunctionRelA/SpoT family protein
Trusted Cutoff499.20
Domain Trusted Cutoff499.20
Noise Cutoff337.65
Domain Noise Cutoff337.65
Isology Typesubfamily
HMM Length687
Mainrole CategoryCellular processes
Subrole CategoryAdaptations to atypical conditions
Gene Ontology TermGO:0003824: catalytic activity molecular_function
GO:0015968: stringent response biological_process
GO:0015969: guanosine tetraphosphate metabolic process biological_process
AuthorHaft DH, Loftus BJ
Entry DateJan 13 2000 2:41PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe functions of E. coli RelA and SpoT differ somewhat. RelA (EC produces pppGpp (or ppGpp) from ATP and GTP (or GDP). SpoT (EC degrades ppGpp, but may also act as a secondary ppGpp synthetase. The two proteins are strongly similar. In many species, a single homolog to SpoT and RelA appears reponsible for both ppGpp synthesis and ppGpp degradation. (p)ppGpp is a regulatory metabolite of the stringent response, but appears also to be involved in antibiotic biosynthesis in some species.
ReferencesA2 hmmalign DR ECOCYC; EG10835; relA DR ECOCYC; EG10966; spoT