HMM Summary Page: TIGR00687

Functionpyridoxal kinase
Trusted Cutoff144.50
Domain Trusted Cutoff144.50
Noise Cutoff73.45
Domain Noise Cutoff73.45
Isology Typeequivalog
EC Number2.7.1.35
HMM Length288
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryPyridoxine
Gene Ontology TermGO:0008478: pyridoxal kinase activity molecular_function
GO:0009443: pyridoxal 5'-phosphate salvage biological_process
AuthorHaft DH, Loftus BJ
Entry DateJan 13 2000 2:40PM
Last ModifiedFeb 14 2011 3:27PM
CommentE. coli has an enzyme PdxK that acts in vitro as a pyridoxine/pyridoxal/pyridoxamine kinase, but mutants lacking PdxK activity retain a specific pyridoxal kinase, PdxY. PdxY acts in the salvage pathway of pyridoxal 5'-phosphate biosynthesis. Mammalian forms of pyridoxal kinase are more similar to PdxY than to PdxK. The PdxK isozyme is omitted from the seed alignment but scores above the trusted cutoff. ThiD and related proteins form an outgroup.
ReferencesAL clustalW RN [1] RM 98196726 RN [2] RM 96291683 DR EXPERIMENTAL; EGAD|91884|EC1636; pdxY DR EXPERIMENTAL; EGAD|30575|EC2418; pdxK DR EXPERIMENTAL; GP|2773404|gb|AAB96794.1||AF041255 DR OUTGROUP; EGAD|21177|BS3795 DR OUTGROUP; EGAD|89357|HP0844 DR HAMAP; MF_01639; 57 of 58