HMM Summary Page: TIGR00682

Functiontetraacyldisaccharide 4'-kinase
Gene SymbollpxK
Trusted Cutoff91.95
Domain Trusted Cutoff91.95
Noise Cutoff72.90
Domain Noise Cutoff72.90
Isology Typeequivalog
EC Number2.7.1.130
HMM Length324
Mainrole CategoryCell envelope
Subrole CategoryBiosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Gene Ontology TermGO:0009029: tetraacyldisaccharide 4'-kinase activity molecular_function
GO:0009245: lipid A biosynthetic process biological_process
AuthorHaft DH
Entry DateJan 13 2000 2:40PM
Last ModifiedFeb 14 2011 3:27PM
CommentAlso called lipid-A 4'-kinase. This essential gene encodes an enzyme in the pathway of lipid A biosynthesis in Gram-negative organisms. A single copy of this protein is found in Gram-negative bacteria. PSI-BLAST converges on this set of apparent orthologs without identifying any other homologs.
ReferencesDR InterPro; IPR003758 DR PFAM; PF02606 DR EXPERIMENTAL; EGAD|6890|EC0915; Escherichia coli DR ECOCYC; EG11409; lpxK RN [1] RM 98241618 RT Accumulation of a lipid A precursor lacking the 4'-phosphate following inactivation of the Escherichia coli lpxK gene. RA Garrett TA, Que NL, Raetz CR RL J Biol Chem 1998 May 15;273(20):12457-65 DR HAMAP; MF_00409; 250 of 263
Genome PropertyGenProp0204: KDO(2)-lipid A (Re LPS) biosynthesis and delivery (HMM)