| Accession | TIGR00682 |
| Name | lpxK |
| Function | tetraacyldisaccharide 4'-kinase |
| Gene Symbol | lpxK |
| Trusted Cutoff | 91.95 |
| Domain Trusted Cutoff | 91.95 |
| Noise Cutoff | 72.90 |
| Domain Noise Cutoff | 72.90 |
| Isology Type | equivalog |
| EC Number | 2.7.1.130 |
| HMM Length | 324 |
| Mainrole Category | Cell envelope |
| Subrole Category | Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides |
| Gene Ontology Term | GO:0009029: tetraacyldisaccharide 4'-kinase activity molecular_function |
| | GO:0009245: lipid A biosynthetic process biological_process |
| Author | Haft DH |
| Entry Date | Jan 13 2000 2:40PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Also called lipid-A 4'-kinase. This essential gene encodes an enzyme in the pathway of lipid A biosynthesis in Gram-negative organisms. A single copy of this protein is found in Gram-negative bacteria. PSI-BLAST converges on this set of apparent orthologs without identifying any other homologs. |
| References | DR InterPro; IPR003758
DR PFAM; PF02606
DR EXPERIMENTAL; EGAD|6890|EC0915; Escherichia coli
DR ECOCYC; EG11409; lpxK
RN [1]
RM 98241618
RT Accumulation of a lipid A precursor lacking the 4'-phosphate following inactivation of the Escherichia coli lpxK gene.
RA Garrett TA, Que NL, Raetz CR
RL J Biol Chem 1998 May 15;273(20):12457-65
DR HAMAP; MF_00409; 250 of 263 |
| Genome Property | GenProp0204: KDO(2)-lipid A (Re LPS) biosynthesis and delivery (HMM) |
