| Accession | TIGR00678 |
| Name | holB |
| Function | DNA polymerase III, delta' subunit |
| Gene Symbol | holB |
| Trusted Cutoff | 180.60 |
| Domain Trusted Cutoff | 180.60 |
| Noise Cutoff | 161.00 |
| Domain Noise Cutoff | 161.00 |
| Isology Type | equivalog_domain |
| EC Number | 2.7.7.7 |
| HMM Length | 188 |
| Mainrole Category | DNA metabolism |
| Subrole Category | DNA replication, recombination, and repair |
| Gene Ontology Term | GO:0003887: DNA-directed DNA polymerase activity molecular_function |
| | GO:0006260: DNA replication biological_process |
| | GO:0009360: DNA polymerase III complex cellular_component |
| Author | Haft DH, Loftus BJ |
| Entry Date | Jan 13 2000 2:40PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This model describes the N-terminal half of the delta' subunit of DNA polymerase III. Delta' is homologous to the gamma and tau subunits, which form an outgroup for phylogenetic comparison. The gamma/tau branch of the tree is much more tighly conserved than the delta' branch, and some members of that branch score more highly against this model than some proteins classisified as delta'. The noise cutoff is set to detect weakly scoring delta' subunits rather than to exclude gamma/tau subunits.
At position 126-127 of the seed alignment, this family lacks the HM motif of gamma/tau; at 132 it has a near-invariant A vs. an invariant F in gamma/tau. |
| References | A2 hmmalign
DR EXPERIMETNAL; GB|AAF98347.2; Streptococcus pyogenes
DR EXPERIMENTAL; PIR|D70432; Aquifex aeolicus
DR EXPERIMENTAL; EGAD|20293|EC1099; Escherichia coli
DR OUTGROUP; PIR|A70460; DnaX; Aquifex aeolicus
DR OUTGROUP; SP|P06710; DnaX; Escherichia coli |
| Genome Property | GenProp0263: DNA polymerase III, bacterial (HMM) |
