HMM Summary Page: TIGR00677

Functionmethylenetetrahydrofolate reductase
Trusted Cutoff310.05
Domain Trusted Cutoff310.05
Noise Cutoff301.80
Domain Noise Cutoff301.80
Isology Typeequivalog
EC Number1.5.1.20
HMM Length281
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryFolic acid
Gene Ontology TermGO:0004489: methylenetetrahydrofolate reductase (NADPH) activity molecular_function
GO:0009396: folic acid-containing compound biosynthetic process biological_process
AuthorLoftus BJ, Haft DH
Entry DateJan 13 2000 2:40PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe enzyme activities methylenetetrahydrofolate reductase (EC and 5,10-methylenetetrahydrofolate reductase (FADH) (EC differ in that (assigned in many eukaryotes) is defined to use NADP+ as an acceptor, while (assigned in many bacteria) is flexible with respect to the acceptor; both convert 5-methyltetrahydrofolate to 5,10-methylenetetrahydrofolate. From a larger set of proteins assigned as and, this model describes the subset of proteins found in eukaryotes and designated This protein is an FAD-containing flavoprotein.
ReferencesA2 hmmalign SE COG/EC AL clustalw DR OUTGROUP; EGAD|20689|EC3941; Escherichia coli DR EXPERIMENTAL; EGAD|4286|4234; Homo sapiens DR EXPERIMENTAL; GP|5911425|gb|AAD55787.1|AF181966_1|AF181966