HMM Summary Page: TIGR00676

Functionmethylenetetrahydrofolate reductase [NAD(P)H]
Gene SymbolmetF
Trusted Cutoff293.70
Domain Trusted Cutoff293.70
Noise Cutoff289.85
Domain Noise Cutoff289.85
Isology Typeequivalog
EC Number1.5.1.20
HMM Length275
Mainrole CategoryAmino acid biosynthesis
Subrole CategoryAspartate family
Gene Ontology TermGO:0004489: methylenetetrahydrofolate reductase (NADPH) activity molecular_function
GO:0009086: methionine biosynthetic process biological_process
AuthorLoftus BJ, Haft DH
Entry DateJan 13 2000 2:40PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe enzyme activities methylenetetrahydrofolate reductase (EC and 5,10-methylenetetrahydrofolate reductase (FADH) (EC differ in that (assigned in many eukaryotes) is defined to use NADP+ as an acceptor, while (assigned in many bacteria) is flexible with respect to the acceptor; both convert 5-methyltetrahydrofolate to 5,10-methylenetetrahydrofolate. From a larger set of proteins assigned as and, this model describes the subset of proteins found in bacteria, and currently designated This protein is an FAD-containing flavoprotein.
ReferencesRN [1] RM 99215588 RT The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia. RA Guenther BD, Sheppard CA, Tran P, Rozen R, Matthews RG, Ludwig ML RL Nat Struct Biol 1999 Apr;6(4):359-65 DR ECOCYC; EG10585; metF DR EXPERIMENTAL; EGAD|20689|EC3941; Escherichia coli DR OUTGROUP; EGAD|145028|154652; Schizosaccharomyces pombe DR OUTGROUP; EGAD|4286|4234; Homo sapiens
Genome PropertyGenProp0161: methionine biosynthesis from homoserine (HMM)