| Accession | TIGR00671 |
| Name | baf |
| Function | pantothenate kinase, type III |
| Gene Symbol | coaX |
| Trusted Cutoff | 58.20 |
| Domain Trusted Cutoff | 58.20 |
| Noise Cutoff | 52.45 |
| Domain Noise Cutoff | 52.45 |
| Isology Type | subfamily |
| EC Number | 2.7.1.33 |
| HMM Length | 243 |
| Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
| Subrole Category | Pantothenate and coenzyme A |
| Gene Ontology Term | GO:0004594: pantothenate kinase activity molecular_function |
| | GO:0015937: coenzyme A biosynthetic process biological_process |
| Author | Haft DH |
| Entry Date | Jan 13 2000 2:40PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This HMM describes a family of proteins found in a single copy in at least ten different early completed bacterial genomes. The only characterized member of the family is Bvg accessory factor (Baf), a protein required, in addition to the regulatory operon bvgAS, for heterologous transcription of the Bordetella pertussis toxin operon (ptx) in E. coli. |
| References | RM 95325323
RT Identification of a Bordetella pertussis regulatory factor required for transcription of the pertussis toxin operon in Escherichia coli.
RA DeShazer D, Wood GE, Friedman RL
RL J Bacteriol 1995 Jul;177(13):3801-7
RM 17323930
RT Structure of the type III pantothenate kinase from Bacillus anthracis at 2.0 A resolution: implications for coenzyme A-dependent redox biology.
RA Nicely NI, Parsonage D, Paige C, Newton GL, Fahey RC, Leonardi R, Jackowski S, Mallett TC, Claiborne A.
RL Biochemistry. 2007 Mar 20;46(11):3234-45. Epub 2007 Feb 27.
DR HAMAP; MF_01274; 264 of 265 |
| Genome Property | GenProp0171: coenzyme A biosynthesis from pantothenate (HMM) |
