HMM Summary Page: TIGR00671

Functionpantothenate kinase, type III
Gene SymbolcoaX
Trusted Cutoff58.20
Domain Trusted Cutoff58.20
Noise Cutoff52.45
Domain Noise Cutoff52.45
Isology Typesubfamily
EC Number2.7.1.33
HMM Length243
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryPantothenate and coenzyme A
Gene Ontology TermGO:0004594: pantothenate kinase activity molecular_function
GO:0015937: coenzyme A biosynthetic process biological_process
AuthorHaft DH
Entry DateJan 13 2000 2:40PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes a family of proteins found in a single copy in at least ten different early completed bacterial genomes. The only characterized member of the family is Bvg accessory factor (Baf), a protein required, in addition to the regulatory operon bvgAS, for heterologous transcription of the Bordetella pertussis toxin operon (ptx) in E. coli.
ReferencesRM 95325323 RT Identification of a Bordetella pertussis regulatory factor required for transcription of the pertussis toxin operon in Escherichia coli. RA DeShazer D, Wood GE, Friedman RL RL J Bacteriol 1995 Jul;177(13):3801-7 RM 17323930 RT Structure of the type III pantothenate kinase from Bacillus anthracis at 2.0 A resolution: implications for coenzyme A-dependent redox biology. RA Nicely NI, Parsonage D, Paige C, Newton GL, Fahey RC, Leonardi R, Jackowski S, Mallett TC, Claiborne A. RL Biochemistry. 2007 Mar 20;46(11):3234-45. Epub 2007 Feb 27. DR HAMAP; MF_01274; 264 of 265
Genome PropertyGenProp0171: coenzyme A biosynthesis from pantothenate (HMM)