HMM Summary Page: TIGR00669

Functionaspartate--ammonia ligase
Gene SymbolasnA
Trusted Cutoff292.80
Domain Trusted Cutoff292.80
Noise Cutoff185.40
Domain Noise Cutoff185.40
Isology Typeequivalog
EC Number6.3.1.1
HMM Length330
Mainrole CategoryAmino acid biosynthesis
Subrole CategoryAspartate family
Gene Ontology TermGO:0004071: aspartate-ammonia ligase activity molecular_function
GO:0006529: asparagine biosynthetic process biological_process
AuthorLoftus BJ, Haft DH
Entry DateJan 13 2000 2:40PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents one of two non-homologous forms of aspartate--ammonia ligase (asparagine synthetase) found in E. coli. This type is also found in Haemophilus influenzae, Treponema pallidum and Lactobacillus delbrueckii, but appears to have a very limited distribution. The fact that the protein from the H. influenzae is more than 70 % identical to that from the spirochete Treponema pallidum, but less than 65 % identical to that from the closely related E. coli, strongly suggests lateral transfer.
ReferencesAL clustalw_manual DR HAMAP; MF_00555; 89 of 93
Genome PropertyGenProp0259: tRNA-Asn direct aminoacylation (HMM)