Accession | TIGR00667 |
Name | aat |
Function | leucyl/phenylalanyl-tRNA--protein transferase |
Gene Symbol | aat |
Trusted Cutoff | 143.55 |
Domain Trusted Cutoff | 143.55 |
Noise Cutoff | 66.55 |
Domain Noise Cutoff | 66.55 |
Isology Type | equivalog |
EC Number | 2.3.2.6 |
HMM Length | 193 |
Mainrole Category | Protein fate |
Subrole Category | Degradation of proteins, peptides, and glycopeptides |
Gene Ontology Term | GO:0006508: proteolysis biological_process |
| GO:0008914: leucyltransferase activity molecular_function |
Author | Haft DH, Loftus BJ |
Entry Date | Jan 13 2000 2:40PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | The N-terminal residue controls the biological half-life of many proteins via the N-end rule pathway. This enzyme transfers a Leu or Phe to the amino end of certain proteins to enable degradation. |
References | SE EC/COG
AL clustalw
RN [1]
RM 93322314
RT The N-end rule in Escherichia coli: cloning and analysis of the leucyl, phenylalanyl-tRNA-protein transferase gene aat.
RA Shrader TE, Tobias JW, Varshavsky A
RL J Bacteriol 1993 Jul;175(14):4364-74
RN [2]
RM 95386512
DR ECOCYC; EG11112; aat
DR EXPERIMENTAL; EGAD|20052|EC0885; Escherichia coli
DR HAMAP; MF_00688; 213 of 216 |