HMM Summary Page: TIGR00666

FunctionD-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase
Gene SymboldacB
Trusted Cutoff107.80
Domain Trusted Cutoff107.80
Noise Cutoff75.45
Domain Noise Cutoff75.45
Isology Typeequivalog
EC Number3.4.16.4
HMM Length397
Mainrole CategoryCell envelope
Subrole CategoryBiosynthesis and degradation of murein sacculus and peptidoglycan
Gene Ontology TermGO:0008717: D-alanyl-D-alanine endopeptidase activity molecular_function
GO:0009002: serine-type D-Ala-D-Ala carboxypeptidase activity molecular_function
GO:0009252: peptidoglycan biosynthetic process biological_process
AuthorHaft DH, Loftus BJ
Entry DateJan 13 2000 2:40PM
Last ModifiedFeb 14 2011 3:27PM
CommentIn E. coli, this protein is known as penicillin binding protein 4 (dacB). A signal sequence is cleaved from a precursor form. The protein is described as periplasmic in E. coli (Gram-negative) and extracellular in Actinomadura R39 (Gram-positive). Unlike some other proteins with similar activity, it does not form transpeptidation. It is not essential for viability. This family is related to class A beta-lactamases.
ReferencesA2 hmmalign AL manual RN [1] RM 91250093 RN [2] RM 92207168 RT Primary and predicted secondary structures of the Actinomadura R39 extracellular DD-peptidase, a penicillin-binding protein (PBP) related to the Escherichia coli PBP4. RA Granier B, Duez C, Lepage S, Englebert S, Dusart J, Dideberg O, Van Beeumen J, Frere JM, Ghuysen JM RL Biochem J 1992 Mar 15;282 ( Pt 3):781-8 DR ECOCYC; EG10202; dacB