| Accession | TIGR00665 |
| Name | DnaB |
| Function | replicative DNA helicase |
| Gene Symbol | dnaB |
| Trusted Cutoff | 385.25 |
| Domain Trusted Cutoff | 385.25 |
| Noise Cutoff | 248.10 |
| Domain Noise Cutoff | 248.10 |
| Isology Type | equivalog |
| EC Number | 3.6.4.12 |
| HMM Length | 435 |
| Mainrole Category | DNA metabolism |
| Subrole Category | DNA replication, recombination, and repair |
| Gene Ontology Term | GO:0004003: ATP-dependent DNA helicase activity molecular_function |
| | GO:0006260: DNA replication biological_process |
| Author | Haft DH |
| Entry Date | Jan 13 2000 2:40PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This HMM describes the helicase DnaB, a homohexameric protein required for DNA replication. The homohexamer can form a ring around a single strand of DNA near a replication fork. An intein of > 400 residues is found at a conserved location in DnaB of Synechocystis PCC6803, Rhodothermus marinus (both experimentally confirmed), and Mycobacterium tuberculosis. The intein removes itself by a self-splicing reaction. The seed alignment contains inteins so that the model built from the seed alignment will model a low cost at common intein insertion sites. |
| References | DR PFAM; PF00772; DnaB
DR EXPERIMENTAL; EGAD|5615|EC4052
DR EXPERIMENTAL; GP|4416322|gb|AAD20314.1||AF106032; Bacillus stearothermophilus
DR ECOCYC; EG10236; dnaB; |
| Genome Property | GenProp0806: replication initiation, bacterial (HMM) |
| | GenProp0800: bacterial core gene set, 1 or more per genome (HMM) |
