HMM Summary Page: TIGR00665

Functionreplicative DNA helicase
Gene SymboldnaB
Trusted Cutoff385.25
Domain Trusted Cutoff385.25
Noise Cutoff248.10
Domain Noise Cutoff248.10
Isology Typeequivalog
EC Number3.6.4.12
HMM Length435
Mainrole CategoryDNA metabolism
Subrole CategoryDNA replication, recombination, and repair
Gene Ontology TermGO:0004003: ATP-dependent DNA helicase activity molecular_function
GO:0006260: DNA replication biological_process
AuthorHaft DH
Entry DateJan 13 2000 2:40PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes the helicase DnaB, a homohexameric protein required for DNA replication. The homohexamer can form a ring around a single strand of DNA near a replication fork. An intein of > 400 residues is found at a conserved location in DnaB of Synechocystis PCC6803, Rhodothermus marinus (both experimentally confirmed), and Mycobacterium tuberculosis. The intein removes itself by a self-splicing reaction. The seed alignment contains inteins so that the model built from the seed alignment will model a low cost at common intein insertion sites.
ReferencesDR PFAM; PF00772; DnaB DR EXPERIMENTAL; EGAD|5615|EC4052 DR EXPERIMENTAL; GP|4416322|gb|AAD20314.1||AF106032; Bacillus stearothermophilus DR ECOCYC; EG10236; dnaB;
Genome PropertyGenProp0806: replication initiation, bacterial (HMM)
GenProp0800: bacterial core gene set, 1 or more per genome (HMM)