HMM Summary Page: TIGR00659

FunctionTIGR00659 family protein
Trusted Cutoff249.70
Domain Trusted Cutoff249.70
Noise Cutoff174.15
Domain Noise Cutoff174.15
Isology Typehypoth_equivalog
HMM Length226
Mainrole CategoryHypothetical proteins
Subrole CategoryConserved
AuthorHaft DH
Entry DateDec 8 1999 11:28AM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this small but broadly distibuted (Gram-positive, Gram-negative, and Archaeal) family appear to have multiple transmembrane segments. The function is unknown. A homolog, LrgB of Staphylococcus aureus, in the same small superfamily but in an outgroup to this subfamily, is regulated by LytSR and is suggested to act as a murein hydrolase. Of the three paralogous proteins in B. subtilis, one is a full length member of this family, one lacks the C-terminal 60 residues and has an additional 128 N-terminal residues but branches within the family in a phylogenetic tree, and one is closely related to LrgB and part of the outgroup.
ReferencesA2 hmmalign GA hmmsearch DR OUTGROUP; EGAD|107753|BS2884; DR OUTGROUP; GP|1575026|gb|AAC44840.1||U52961; Staphylococcus aureus LrgB; RM 96422016