HMM Summary Page: TIGR00658

Functionornithine carbamoyltransferase
Gene SymbolargF
Trusted Cutoff280.85
Domain Trusted Cutoff280.85
Noise Cutoff175.35
Domain Noise Cutoff175.35
Isology Typeequivalog
EC Number2.1.3.3
HMM Length304
Mainrole CategoryAmino acid biosynthesis
Subrole CategoryGlutamate family
Gene Ontology TermGO:0004585: ornithine carbamoyltransferase activity molecular_function
GO:0042450: arginine biosynthetic process via ornithine biological_process
AuthorHaft DH
Entry DateDec 1 1999 10:45AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family of ornithine carbamoyltransferases (OTCase) is in a superfamily with the related enzyme aspartate carbamoyltransferase. Most known examples are anabolic, playing a role in arginine biosynthesis, but some are catabolic. Most OTCases are homotrimers, but the homotrimers are organized into dodecamers built from four trimers in at least two species; the catabolic OTCase of Pseudomonas aeruginosa is allosterically regulated, while OTCase of the extreme thermophile Pyrococcus furiosus shows both allostery and thermophily.
ReferencesAL Clustalw DR PFAM; PF00185; OTCace DR PROSITE; PDOC00091; RN [1] RM 98169451 RN [2] DR HAMAP; MF_01109; 303 of 307
Genome PropertyGenProp0117: arginine biosynthesis from ornithine, carbamoyl-p and aspartate (HMM)
GenProp0639: arginine degradation via citrulline, ATP-generating (HMM)