| Accession | TIGR00658 |
| Name | orni_carb_tr |
| Function | ornithine carbamoyltransferase |
| Gene Symbol | argF |
| Trusted Cutoff | 280.85 |
| Domain Trusted Cutoff | 280.85 |
| Noise Cutoff | 175.35 |
| Domain Noise Cutoff | 175.35 |
| Isology Type | equivalog |
| EC Number | 2.1.3.3 |
| HMM Length | 304 |
| Mainrole Category | Amino acid biosynthesis |
| Subrole Category | Glutamate family |
| Gene Ontology Term | GO:0004585: ornithine carbamoyltransferase activity molecular_function |
| | GO:0042450: arginine biosynthetic process via ornithine biological_process |
| Author | Haft DH |
| Entry Date | Dec 1 1999 10:45AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This family of ornithine carbamoyltransferases (OTCase) is in a superfamily with the related enzyme aspartate carbamoyltransferase. Most known examples are anabolic, playing a role in arginine biosynthesis, but some are catabolic.
Most OTCases are homotrimers, but the homotrimers are organized into dodecamers built from four trimers in at least two species; the catabolic OTCase of Pseudomonas aeruginosa is allosterically regulated, while OTCase of the extreme thermophile Pyrococcus furiosus shows both allostery and thermophily. |
| References | AL Clustalw
DR PFAM; PF00185; OTCace
DR PROSITE; PDOC00091;
RN [1]
RM 98169451
RN [2]
DR HAMAP; MF_01109; 303 of 307 |
| Genome Property | GenProp0117: arginine biosynthesis from ornithine, carbamoyl-p and aspartate (HMM) |
| | GenProp0639: arginine degradation via citrulline, ATP-generating (HMM) |
