HMM Summary Page: TIGR00655

Functionformyltetrahydrofolate deformylase
Gene SymbolpurU
Trusted Cutoff285.95
Domain Trusted Cutoff285.95
Noise Cutoff170.60
Domain Noise Cutoff170.60
Isology Typeequivalog
EC Number3.5.1.10
HMM Length280
Mainrole CategoryPurines, pyrimidines, nucleosides, and nucleotides
Subrole CategoryPurine ribonucleotide biosynthesis
Gene Ontology TermGO:0008864: formyltetrahydrofolate deformylase activity molecular_function
GO:0009152: purine ribonucleotide biosynthetic process biological_process
AuthorHaft DH
Entry DateDec 1 1999 10:45AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes formyltetrahydrofolate deformylases. The enzyme is a homohexamer. Sequences from a related enzyme formyl tetrahydrofolate-specific enzyme, phosphoribosylglycinamide formyltransferase, serve as an outgroup for phylogenetic analysis. Putative members of this family, scoring below the trusted cutoff, include a sequence from Rhodobacter capsulatus that lacks an otherwise conserved C-terminal region.
ReferencesA2 hmmalign AL Clustalw DR PFAM; PF00551; formyl_transf RN [1] RM 95173107 RT Formyltetrahydrofolate hydrolase, a regulatory enzyme that functions to balance pools of tetrahydrofolate and one-carbon tetrahydrofolate adducts in Escherichia coli. RA Nagy PL, Marolewski A, Benkovic SJ, Zalkin H RL J Bacteriol 1995 Mar;177(5):1292-8 RN [2] RM 94042872 RT purU, a source of formate for purT-dependent phosphoribosyl-N-formylglycinamide synthesis. RA Nagy PL, McCorkle GM, Zalkin H RL J Bacteriol 1993 Nov;175(21):7066-73 DR SWISSPROT; P37051; PURU_ECOLI; DR OUTGROUP; EGAD|18449|EC2500; DR EXPERIMENTAL; EGAD|15350|EC1232;