HMM Summary Page: TIGR00653

Functionglutamine synthetase, type I
Gene SymbolglnA
Trusted Cutoff429.15
Domain Trusted Cutoff429.15
Noise Cutoff324.75
Domain Noise Cutoff324.75
Isology Typeequivalog
EC Number6.3.1.2
HMM Length462
Mainrole CategoryAmino acid biosynthesis
Subrole CategoryGlutamate family
Gene Ontology TermGO:0004356: glutamate-ammonia ligase activity molecular_function
GO:0006542: glutamine biosynthetic process biological_process
AuthorHaft DH
Entry DateDec 1 1999 10:45AM
Last ModifiedFeb 14 2011 3:27PM
CommentAlternate name: glutamate--ammonia ligase. This model represents the dodecameric form, which can be subdivided into 1-alpha and 1-beta forms. The phylogeny of the 1-alpha and 1-beta forms appears polyphyletic. E. coli, Synechocystis PCC6803, Aquifex aeolicus, and the crenarcheon Sulfolobus acidocaldarius have form 1-beta, while Bacillus subtilis, Thermotoga maritima, and various euryarchaea has form 1-alpha. The 1-beta dodecamer from the crenarcheon Sulfolobus acidocaldarius differs from that in E. coli in that it is not regulated by adenylylation.
ReferencesA2 hmmalign DR ECOCYC; EG10383; glnA; DR EXPERIMENTAL; EGAD|20324|EC3870; DR EXPERIMENTAL; EGAD|8994|8799; RN [1] RM 99081206 RT The glutamine synthetase from the hyperthermoacidophilic crenarcheon Sulfolobus acidocaldarius: isolation, characterization and sequencing of the gene. RA Yin Z, Purschke WG, Schafer G, Schmidt CL RL Biol Chem 1998 Nov;379(11):1349-54 RN [2] RM 95214531 RT Glutamine synthetase gene evolution in bacteria. RA Pesole G, Gissi C, Lanave C, Saccone C RL Mol Biol Evol 1995 Mar;12(2):189-97