HMM Summary Page: TIGR00646

FunctionDNA primase-like protein
Trusted Cutoff260.65
Domain Trusted Cutoff260.65
Noise Cutoff260.50
Domain Noise Cutoff260.50
Isology Typehypoth_equivalog
HMM Length218
Mainrole CategoryUnknown function
Subrole CategoryGeneral
AuthorHaft DH, Loftus BJ
Entry DateNov 3 1999 10:19AM
Last ModifiedFeb 25 2011 12:36PM
CommentThe DNA primase DnaG of E. coli and its apparent orthologs in other eubacterial species are approximately 600 residues in length. Within this set, a conspicuous outlier in percent identity, as seen in a UPGMA difference tree, is the branch containing the Mycoplasmas. This lineage is also unique in containing the small, DNA primase-related protein modelled by this HMM, which is homologous to the central third of DNA primase. Several small regions of sequence similarity specifically to Mycoplasma sequences rather than to all DnaG homologs suggests that the divergence of this protein from DnaG post-dated the separation of bacterial lineages. The function of this DNA primase-related protein is unknown.
ReferencesA2 hmmalign GA hmmsearch DR EGAD; 31223; DR SWISSPROT; P47256;