HMM Summary Page: TIGR00637

FunctionModE molybdate transport repressor domain
Trusted Cutoff98.50
Domain Trusted Cutoff98.50
Noise Cutoff22.20
Domain Noise Cutoff22.20
Isology Typesubfamily_domain
HMM Length100
Mainrole CategoryRegulatory functions
Subrole CategoryOther
AuthorHaft DH
Entry DateOct 25 1999 11:40AM
Last ModifiedFeb 14 2011 3:27PM
CommentModE is a molybdate-activated repressor of the molybdate transport operon in E. coli. It consists of the domain represented by this HMM and two tandem copies of mop-like domain, where Mop proteins are a family of 68-residue molybdenum-pterin binding proteins of Clostridium pasteurianum. This HMM also represents the full length of a pair of archaeal proteins that lack Mop-like domains. PSI-BLAST analysis shows similarity to helix-turn-helix regulatory proteins.
ReferencesA2 hmmalign AL ClustalW RM 96146523 RT Repression of the Escherichia coli modABCD (molybdate transport) operon by ModE. RA Grunden AM, Ray RM, Rosentel JK, Healy FG, Shanmugam KT RL J Bacteriol 1996 Feb;178(3):735-44
Genome PropertyGenProp0192: molybdate ABC transporter (HMM)