| Accession | TIGR00635 |
| Name | ruvB |
| Function | Holliday junction DNA helicase RuvB |
| Gene Symbol | ruvB |
| Trusted Cutoff | 299.05 |
| Domain Trusted Cutoff | 299.05 |
| Noise Cutoff | 191.30 |
| Domain Noise Cutoff | 191.30 |
| Isology Type | equivalog |
| EC Number | 3.6.4.12 |
| HMM Length | 305 |
| Mainrole Category | DNA metabolism |
| Subrole Category | DNA replication, recombination, and repair |
| Gene Ontology Term | GO:0006310: DNA recombination biological_process |
| | GO:0009378: four-way junction helicase activity molecular_function |
| | GO:0009379: Holliday junction helicase complex cellular_component |
| Author | Loftus BJ, Eisen JA |
| Entry Date | Oct 20 1999 2:28PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | All proteins in this family for which functions are known are 5'-3' DNA helicases that, as part of a complex with RuvA homologs serve as a 5'-3' Holliday junction helicase.
RuvA specifically binds Holliday junctions as a sandwich of two tetramers and maintains the configuration of the junction. It forms a complex with two hexameric rings of RuvB, the subunit that contains helicase activity. The complex drives ATP-dependent branch migration of the Holliday junction recombination intermediate. The endonuclease RuvC resolves junctions. |
| References | GA hmmsearch
RM 88314937;
DR SWISSPROT; P08577;
DR EGAD; 15420;
RN [1]
RM 98105106
RT Processing of recombination intermediates by the RuvABC proteins.
RA West SC
RL Annu Rev Genet 1997;31:213-44
DR HAMAP; MF_00016; 522 of 528 |
| Genome Property | GenProp0198: ruvABC Holliday junction complex (HMM) |
