HMM Summary Page: TIGR00635

FunctionHolliday junction DNA helicase RuvB
Gene SymbolruvB
Trusted Cutoff299.05
Domain Trusted Cutoff299.05
Noise Cutoff191.30
Domain Noise Cutoff191.30
Isology Typeequivalog
EC Number3.6.4.12
HMM Length305
Mainrole CategoryDNA metabolism
Subrole CategoryDNA replication, recombination, and repair
Gene Ontology TermGO:0006310: DNA recombination biological_process
GO:0009378: four-way junction helicase activity molecular_function
GO:0009379: Holliday junction helicase complex cellular_component
AuthorLoftus BJ, Eisen JA
Entry DateOct 20 1999 2:28PM
Last ModifiedFeb 14 2011 3:27PM
CommentAll proteins in this family for which functions are known are 5'-3' DNA helicases that, as part of a complex with RuvA homologs serve as a 5'-3' Holliday junction helicase. RuvA specifically binds Holliday junctions as a sandwich of two tetramers and maintains the configuration of the junction. It forms a complex with two hexameric rings of RuvB, the subunit that contains helicase activity. The complex drives ATP-dependent branch migration of the Holliday junction recombination intermediate. The endonuclease RuvC resolves junctions.
ReferencesGA hmmsearch RM 88314937; DR SWISSPROT; P08577; DR EGAD; 15420; RN [1] RM 98105106 RT Processing of recombination intermediates by the RuvABC proteins. RA West SC RL Annu Rev Genet 1997;31:213-44 DR HAMAP; MF_00016; 522 of 528
Genome PropertyGenProp0198: ruvABC Holliday junction complex (HMM)