HMM Summary Page: TIGR00619

Functionexonuclease SbcCD, D subunit
Gene SymbolsbcD
Trusted Cutoff77.65
Domain Trusted Cutoff77.65
Noise Cutoff67.25
Domain Noise Cutoff67.25
Isology Typesubfamily
HMM Length252
Mainrole CategoryDNA metabolism
Subrole CategoryDNA replication, recombination, and repair
Gene Ontology TermGO:0004527: exonuclease activity molecular_function
GO:0006260: DNA replication biological_process
GO:0006310: DNA recombination biological_process
AuthorLoftus BJ, Eisen JA
Entry DateOct 20 1999 11:56AM
Last ModifiedFeb 14 2011 3:27PM
CommentAll proteins in this family for which functions are known are double-stranded DNA exonuclease (as part of a complex with SbcC homologs). This complex functions in the initiation of recombination and recombinational repair and is particularly important in regulating the stability of DNA sections that can form secondary structures. This family is likely homologous to the MRE11 family. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).
ReferencesA2 hmmalign GA hmmsearch DR EGAD; 9310; DR SWISSPROT; P13457; RM 90045931;