| Accession | TIGR00612 |
| Name | ispG_gcpE |
| Function | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase |
| Gene Symbol | ispG |
| Trusted Cutoff | 280.25 |
| Domain Trusted Cutoff | 280.25 |
| Noise Cutoff | 159.60 |
| Domain Noise Cutoff | 159.60 |
| Isology Type | equivalog |
| EC Number | 1.17.7.1 |
| HMM Length | 357 |
| Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
| Subrole Category | Other |
| Gene Ontology Term | GO:0005737: cytoplasm cellular_component |
| | GO:0019288: isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway biological_process |
| | GO:0046429: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity molecular_function |
| Author | Haft DH |
| Entry Date | Oct 20 1999 11:45AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This protein of previously unknown biochemical function has now been identified as an enzyme of the non-mevalonate pathway of IPP biosynthesis.
Chlamydial members of the family have a long insert. The family is largely restricted to Bacteria, where it is widely but not universally distributed. No homology can be detected between the GcpE family and other proteins. |
| References | RN [1]
RM 11163766
RT Identification of gcpE as a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis in Escherichia coli.
RA Campos N, Rodriguez-Concepcion M, Seemann M, Rohmer M, Boronat A.
RL FEBS Lett 2001 Jan 19;488(3):170-3
RN [2]
RM 97234638
RT aarC, an essential gene involved in density-dependent regulation of the 2'-N-acetyltransferase in Providencia stuartii.
RA Rather PN, Solinsky KA, Paradise MR, Parojcic MM
RL J Bacteriol 1997 Apr;179(7):2267-73
DR HAMAP; MF_00159; 301 of 306 |
| Genome Property | GenProp0048: IPP biosynthesis via deoxyxylulose (HMM) |
