HMM Summary Page: TIGR00612

Function4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase
Gene SymbolispG
Trusted Cutoff280.25
Domain Trusted Cutoff280.25
Noise Cutoff159.60
Domain Noise Cutoff159.60
Isology Typeequivalog
EC Number1.17.7.1
HMM Length357
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryOther
Gene Ontology TermGO:0005737: cytoplasm cellular_component
GO:0019288: isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway biological_process
GO:0046429: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity molecular_function
AuthorHaft DH
Entry DateOct 20 1999 11:45AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis protein of previously unknown biochemical function has now been identified as an enzyme of the non-mevalonate pathway of IPP biosynthesis. Chlamydial members of the family have a long insert. The family is largely restricted to Bacteria, where it is widely but not universally distributed. No homology can be detected between the GcpE family and other proteins.
ReferencesRN [1] RM 11163766 RT Identification of gcpE as a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis in Escherichia coli. RA Campos N, Rodriguez-Concepcion M, Seemann M, Rohmer M, Boronat A. RL FEBS Lett 2001 Jan 19;488(3):170-3 RN [2] RM 97234638 RT aarC, an essential gene involved in density-dependent regulation of the 2'-N-acetyltransferase in Providencia stuartii. RA Rather PN, Solinsky KA, Paradise MR, Parojcic MM RL J Bacteriol 1997 Apr;179(7):2267-73 DR HAMAP; MF_00159; 301 of 306
Genome PropertyGenProp0048: IPP biosynthesis via deoxyxylulose (HMM)