| Accession | TIGR00609 |
| Name | recB |
| Function | exodeoxyribonuclease V, beta subunit |
| Gene Symbol | recB |
| Trusted Cutoff | 696.05 |
| Domain Trusted Cutoff | 696.05 |
| Noise Cutoff | 432.10 |
| Domain Noise Cutoff | 432.10 |
| Isology Type | equivalog |
| EC Number | 3.1.11.5 |
| HMM Length | 1175 |
| Mainrole Category | DNA metabolism |
| Subrole Category | DNA replication, recombination, and repair |
| Gene Ontology Term | GO:0006281: DNA repair biological_process |
| | GO:0006310: DNA recombination biological_process |
| | GO:0008854: exodeoxyribonuclease V activity molecular_function |
| | GO:0009338: exodeoxyribonuclease V complex cellular_component |
| Author | Haft DH, Loftus BJ, Eisen JA |
| Entry Date | Oct 19 1999 6:20PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | The RecBCD holoenzyme is a multifunctional nuclease with potent ATP-dependent exodeoxyribonuclease activity. Ejection of RecD, as occurs at chi recombinational hotspots, cripples exonuclease activity in favor of recombinagenic helicase activity.
All proteins in this family for which functions are known are DNA-DNA helicases that are used as part of an exonuclease-helicase complex (made up of RecBCD homologs) that function to generate substrates for the initiation of recombination and recombinational repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). |
| References | A2 hmmalign
GA hmmsearch
RM 87066729 |
| Genome Property | GenProp0216: recBCD pathway (HMM) |
