HMM Summary Page: TIGR00609

Functionexodeoxyribonuclease V, beta subunit
Gene SymbolrecB
Trusted Cutoff696.05
Domain Trusted Cutoff696.05
Noise Cutoff432.10
Domain Noise Cutoff432.10
Isology Typeequivalog
EC Number3.1.11.5
HMM Length1175
Mainrole CategoryDNA metabolism
Subrole CategoryDNA replication, recombination, and repair
Gene Ontology TermGO:0006281: DNA repair biological_process
GO:0006310: DNA recombination biological_process
GO:0008854: exodeoxyribonuclease V activity molecular_function
GO:0009338: exodeoxyribonuclease V complex cellular_component
AuthorHaft DH, Loftus BJ, Eisen JA
Entry DateOct 19 1999 6:20PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe RecBCD holoenzyme is a multifunctional nuclease with potent ATP-dependent exodeoxyribonuclease activity. Ejection of RecD, as occurs at chi recombinational hotspots, cripples exonuclease activity in favor of recombinagenic helicase activity. All proteins in this family for which functions are known are DNA-DNA helicases that are used as part of an exonuclease-helicase complex (made up of RecBCD homologs) that function to generate substrates for the initiation of recombination and recombinational repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).
ReferencesA2 hmmalign GA hmmsearch RM 87066729
Genome PropertyGenProp0216: recBCD pathway (HMM)