HMM Summary Page: TIGR00600

FunctionDNA excision repair protein (rad2)
Trusted Cutoff1204.40
Domain Trusted Cutoff1204.40
Noise Cutoff316.45
Domain Noise Cutoff316.45
Isology Typesubfamily
HMM Length1039
Mainrole CategoryDNA metabolism
Subrole CategoryDNA replication, recombination, and repair
AuthorLoftus BJ, Eisen JA
Entry DateOct 19 1999 6:19PM
Last ModifiedFeb 14 2011 3:27PM
CommentAll proteins in this family for which functions are known are flap endonucleases that generate the 3' incision next to DNA damage as part of nucleotide excision repair. This family is related to many other flap endonuclease families including the fen1 family. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).
ReferencesA2 hmmalign GA hmmsearch DR SWISSPROT; P07276; RM 86083164;