HMM Summary Page: TIGR00591

Functiondeoxyribodipyrimidine photolyase
Gene SymbolphrB
Trusted Cutoff550.05
Domain Trusted Cutoff550.05
Noise Cutoff251.50
Domain Noise Cutoff251.50
Isology Typesuperfamily
EC Number4.1.99.3
HMM Length453
Mainrole CategoryDNA metabolism
Subrole CategoryDNA replication, recombination, and repair
Gene Ontology TermGO:0003904: deoxyribodipyrimidine photo-lyase activity molecular_function
GO:0006281: DNA repair biological_process
AuthorLoftus BJ, Eisen JA
Entry DateOct 19 1999 6:19PM
Last ModifiedFeb 14 2011 3:27PM
CommentAll proteins in this family for which functions are known are DNA-photolyases used for the direct repair of UV irradiation induced DNA damage. Some repair 6-4 photoproducts while others repair cyclobutane pyrimidine dimers. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).
ReferencesA2 hmmalign GA hmmsearch DR EGAD; 138476; RM 95112825;