HMM Summary Page: TIGR00589

Functionmethylated-DNA--[protein]-cysteine S-methyltransferase
Trusted Cutoff46.40
Domain Trusted Cutoff46.40
Noise Cutoff42.95
Domain Noise Cutoff42.95
Isology Typesuperfamily
EC Number2.1.1.63
HMM Length80
Mainrole CategoryDNA metabolism
Subrole CategoryDNA replication, recombination, and repair
Gene Ontology TermGO:0003908: methylated-DNA-[protein]-cysteine S-methyltransferase activity molecular_function
GO:0006281: DNA repair biological_process
AuthorLoftus BJ, Eisen JA
Entry DateOct 19 1999 6:19PM
Last ModifiedAug 16 2012 8:40AM
CommentAll proteins in this family for which functions are known are involved alkyl-DNA transferases which remove alkyl groups from DNA as part of alkylation DNA repair. Some of the proteins in this family are also transcription regulators and have a distinct transcription regulatory domain. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).
ReferencesDR SWISSPROT; P06134; DR HAMAP; MF_00772; 16 of 16