HMM Summary Page: TIGR00587

Functionapurinic endonuclease (APN1)
Trusted Cutoff129.65
Domain Trusted Cutoff129.65
Noise Cutoff112.50
Domain Noise Cutoff112.50
Isology Typesubfamily
HMM Length279
Mainrole CategoryDNA metabolism
Subrole CategoryDNA replication, recombination, and repair
Gene Ontology TermGO:0003906: DNA-(apurinic or apyrimidinic site) lyase activity molecular_function
GO:0006281: DNA repair biological_process
AuthorLoftus BJ, Eisen JA
Entry DateOct 19 1999 6:19PM
Last ModifiedFeb 14 2011 3:27PM
CommentAll proteins in this family for which functions are known are 5' AP endonculeases that are used in base excision repair and the repair of abasic sites in DNA.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).
ReferencesGA hmmsearch GA hmmsearch GA hmmsearch DR EGAD; 54020; DR SWISSPROT; P22936; DR HAMAP; MF_00152; 167 of 170