HMM Summary Page: TIGR00586

Functionmutator mutT protein
Trusted Cutoff97.90
Domain Trusted Cutoff97.90
Noise Cutoff43.80
Domain Noise Cutoff43.80
Isology Typesubfamily
EC Number3.6.1.-
HMM Length129
Mainrole CategoryDNA metabolism
Subrole CategoryDNA replication, recombination, and repair
Gene Ontology TermGO:0006281: DNA repair biological_process
GO:0016818: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides molecular_function
AuthorLoftus BJ, Eisen JA
Entry DateOct 19 1999 6:19PM
Last ModifiedFeb 14 2011 3:27PM
CommentAll proteins in this family for which functions are known are involved in repairing oxidative damage to dGTP (they are 8-oxo-dGTPases). This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). Lowering the threshold picks up members of MutT superfamily well.
ReferencesA2 hmmalign GA hmmsearch DR EGAD; 16514; DR SWISSPROT; P08337; RM 87201091;