HMM Summary Page: TIGR00583

FunctionDNA repair protein (mre11)
Trusted Cutoff434.60
Domain Trusted Cutoff434.60
Noise Cutoff203.25
Domain Noise Cutoff203.25
Isology Typeequivalog
HMM Length405
Mainrole CategoryDNA metabolism
Subrole CategoryDNA replication, recombination, and repair
Gene Ontology TermGO:0004519: endonuclease activity molecular_function
GO:0006281: DNA repair biological_process
GO:0006303: double-strand break repair via nonhomologous end joining biological_process
GO:0007004: telomere maintenance via telomerase biological_process
GO:0008408: 3'-5' exonuclease activity molecular_function
AuthorLoftus BJ, Eisen JA
Entry DateOct 19 1999 6:19PM
Last ModifiedFeb 14 2011 3:27PM
CommentAll proteins in this family for which functions are known are subunits of a nuclease complex made up of multiple proteins including MRE11 and RAD50 homologs. The functions of this nuclease complex include recombinational repair and non-homolgous end joining. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). The proteins in this family are distantly related to proteins in the SbcCD complex of bacteria.
ReferencesA2 hmmalign GA hmmsearch DR EGAD; 55138; DR SWISSPROT; P32829; RM 95309669;