HMM Summary Page: TIGR00576

FunctiondUTP diphosphatase
Gene Symboldut
Trusted Cutoff102.55
Domain Trusted Cutoff102.55
Noise Cutoff66.30
Domain Noise Cutoff66.30
Isology Typesuperfamily
EC Number3.6.1.23
HMM Length143
Mainrole CategoryPurines, pyrimidines, nucleosides, and nucleotides
Subrole Category2'-Deoxyribonucleotide metabolism
Gene Ontology TermGO:0004170: dUTP diphosphatase activity molecular_function
GO:0009394: 2'-deoxyribonucleotide metabolic process biological_process
AuthorLoftus BJ, Eisen JA
Entry DateOct 19 1999 6:19PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe main function of these proteins is in maintaining the levels of dUTP in the cell to prevent dUTP incorporation into DNA during DNA replication. Pol proteins in viruses are very similar to this protein family. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). Changed role from 132 to 123. RTD
ReferencesGA hmmsearch GA hmmsearch DR EGAD; 89412; DR SWISSPROT; O41033; DR HAMAP; MF_00116; 285 of 288