HMM Summary Page: TIGR00575

FunctionDNA ligase, NAD-dependent
Gene SymbolligA
Trusted Cutoff444.45
Domain Trusted Cutoff444.45
Noise Cutoff277.20
Domain Noise Cutoff277.20
Isology Typeequivalog
EC Number6.5.1.2
HMM Length652
Mainrole CategoryDNA metabolism
Subrole CategoryDNA replication, recombination, and repair
Gene Ontology TermGO:0003911: DNA ligase (NAD+) activity molecular_function
GO:0006260: DNA replication biological_process
GO:0006281: DNA repair biological_process
GO:0006310: DNA recombination biological_process
AuthorLoftus BJ, Eisen JA, Haft DH
Entry DateOct 19 1999 6:19PM
Last ModifiedFeb 14 2011 3:27PM
CommentAll proteins in this family with known functions are NAD-dependent DNA ligases. Functions of these proteins include DNA repair, DNA replication, and DNA recombination. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). The member of this family from Treponema pallidum differs in having three rather than just one copy of the BRCT (BRCA1 C Terminus) domain (PF00533) at the C-terminus. It is included in the seed.
ReferencesGA hmmsearch DR SWISSPROT; P43813; DR EGAD; 28109; RM 86310292; DR HAMAP; MF_01588; 546 of 556
Genome PropertyGenProp0799: bacterial core gene set, exactly 1 per genome (HMM)