| Accession | TIGR00575 |
| Name | dnlj |
| Function | DNA ligase, NAD-dependent |
| Gene Symbol | ligA |
| Trusted Cutoff | 444.45 |
| Domain Trusted Cutoff | 444.45 |
| Noise Cutoff | 277.20 |
| Domain Noise Cutoff | 277.20 |
| Isology Type | equivalog |
| EC Number | 6.5.1.2 |
| HMM Length | 652 |
| Mainrole Category | DNA metabolism |
| Subrole Category | DNA replication, recombination, and repair |
| Gene Ontology Term | GO:0003911: DNA ligase (NAD+) activity molecular_function |
| | GO:0006260: DNA replication biological_process |
| | GO:0006281: DNA repair biological_process |
| | GO:0006310: DNA recombination biological_process |
| Author | Loftus BJ, Eisen JA, Haft DH |
| Entry Date | Oct 19 1999 6:19PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | All proteins in this family with known functions are NAD-dependent DNA ligases. Functions of these proteins include DNA repair, DNA replication, and DNA recombination. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).
The member of this family from Treponema pallidum differs in having three rather than just one copy of the BRCT (BRCA1 C Terminus) domain (PF00533) at the C-terminus. It is included in the seed. |
| References | GA hmmsearch
DR SWISSPROT; P43813;
DR EGAD; 28109;
RM 86310292;
DR HAMAP; MF_01588; 546 of 556 |
| Genome Property | GenProp0799: bacterial core gene set, exactly 1 per genome (HMM) |
