HMM Summary Page: TIGR00573

Functionexonuclease, DNA polymerase III, epsilon subunit family
Trusted Cutoff71.50
Domain Trusted Cutoff71.50
Noise Cutoff67.40
Domain Noise Cutoff67.40
Isology Typesubfamily_domain
EC Number2.7.7.7
HMM Length217
Mainrole CategoryDNA metabolism
Subrole CategoryDegradation of DNA
Gene Ontology TermGO:0004527: exonuclease activity molecular_function
GO:0006139: nucleobase-containing compound metabolic process biological_process
AuthorLoftus BJ, Eisen JA
Entry DateOct 19 1999 6:19PM
Last ModifiedFeb 14 2011 3:27PM
CommentAll proteins in this family for which functions are known are components of the DNA polymerase III complex (epsilon subunit). There is, however, an outgroup that includes paralogs in some gamma-proteobacteria and the n-terminal region of DinG from some low GC gram positive bacteria. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).
ReferencesGA hmmsearch DR EGAD; 2879; DR SWISSPROT; P43745; DR HAMAP; MF_00356; 64 of 64