HMM Summary Page: TIGR00571

FunctionDNA adenine methylase
Gene Symboldam
Trusted Cutoff114.85
Domain Trusted Cutoff114.85
Noise Cutoff91.70
Domain Noise Cutoff91.70
Isology Typesubfamily
EC Number2.1.1.72
HMM Length267
Mainrole CategoryDNA metabolism
Subrole CategoryDNA replication, recombination, and repair
Gene Ontology TermGO:0006306: DNA methylation biological_process
GO:0009007: site-specific DNA-methyltransferase (adenine-specific) activity molecular_function
AuthorLoftus BJ, Eisen JA, Haft DH
Entry DateOct 19 1999 6:19PM
Last ModifiedFeb 14 2011 3:27PM
CommentAll proteins in this family for which functions are known are DNA-adenine methyltransferases. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). The DNA adenine methylase (dam) of E. coli and related species is instrumental in distinguishing the newly synthesized strand during DNA replication for methylation-directed mismatch repair. This family includes several phage methylases and a number of different restriction enzyme chromosomal site-specific modification systems.
ReferencesA2 hmmalign DR EGAD; 16548; DR SWISSPROT; P00475; RM 83168905;