| Accession | TIGR00571 |
| Name | dam |
| Function | DNA adenine methylase |
| Gene Symbol | dam |
| Trusted Cutoff | 114.85 |
| Domain Trusted Cutoff | 114.85 |
| Noise Cutoff | 91.70 |
| Domain Noise Cutoff | 91.70 |
| Isology Type | subfamily |
| EC Number | 2.1.1.72 |
| HMM Length | 267 |
| Mainrole Category | DNA metabolism |
| Subrole Category | DNA replication, recombination, and repair |
| Gene Ontology Term | GO:0006306: DNA methylation biological_process |
| | GO:0009007: site-specific DNA-methyltransferase (adenine-specific) activity molecular_function |
| Author | Loftus BJ, Eisen JA, Haft DH |
| Entry Date | Oct 19 1999 6:19PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | All proteins in this family for which functions are known are DNA-adenine methyltransferases. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). The DNA adenine methylase (dam) of E. coli and related species is instrumental in distinguishing the newly synthesized strand during DNA replication for methylation-directed mismatch repair. This family includes several phage methylases and a number of different restriction enzyme chromosomal site-specific modification systems. |
| References | A2 hmmalign
DR EGAD; 16548;
DR SWISSPROT; P00475;
RM 83168905; |
