HMM Summary Page: TIGR00570

FunctionCDK-activating kinase assembly factor MAT1
Trusted Cutoff160.20
Domain Trusted Cutoff160.20
Noise Cutoff150.65
Domain Noise Cutoff150.65
Isology Typeequivalog
HMM Length309
Mainrole CategoryDNA metabolism
Subrole CategoryDNA replication, recombination, and repair
Gene Ontology TermGO:0000109: nucleotide-excision repair complex cellular_component
GO:0004693: cyclin-dependent protein kinase activity molecular_function
GO:0005675: holo TFIIH complex cellular_component
GO:0006289: nucleotide-excision repair biological_process
GO:0006352: transcription initiation, DNA-dependent biological_process
AuthorLoftus BJ, Eisen JA
Entry DateOct 19 1999 6:19PM
Last ModifiedFeb 14 2011 3:27PM
CommentAll proteins in this family for which functions are known are cyclin dependent protein kinases that are components of TFIIH, a complex that is involved in nucleotide excision repair and transcription initiation. Also known as MAT1 (menage a trois 1). This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).
ReferencesA2 hmmalign DR EGAD; 96906; DR SWISSPROT: P51949; RM 96006524 RT Alternative mechanisms of CAK assembly require an assembly factor or an activating kinase. RA Fisher RP, Jin P, Chamberlin HM, Morgan DO. RL Cell 1995 Oct 6;83(1):47-57