HMM Summary Page: TIGR00567

FunctionDNA-3-methyladenine glycosylase
Trusted Cutoff116.35
Domain Trusted Cutoff116.35
Noise Cutoff75.80
Domain Noise Cutoff75.80
Isology Typesubfamily
EC Number3.2.2.-
HMM Length192
Mainrole CategoryDNA metabolism
Subrole CategoryDNA replication, recombination, and repair
Gene Ontology TermGO:0006281: DNA repair biological_process
GO:0019104: DNA N-glycosylase activity molecular_function
AuthorLoftus BJ, Eisen JA
Entry DateOct 19 1999 6:19PM
Last ModifiedSep 16 2014 3:59PM
CommentThis families are based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). All proteins in this family for which the function is known are involved in the base excision repair of alkylation damage to DNA. The exact specificty of the type of alkylation damage repaired by each of these varies somewhat between species. Substrates include 3-methyl adenine, 7-methyl-guanaine, and 3-methyl-guanine.
ReferencesDR SWISSPROT; P94378; RM MEDLINE: 97124196; DR HAMAP; MF_00527; 159 of 162