HMM Summary Page: TIGR00562

Functionprotoporphyrinogen oxidase
Gene SymbolhemG
Trusted Cutoff97.85
Domain Trusted Cutoff97.85
Noise Cutoff73.05
Domain Noise Cutoff73.05
Isology Typeequivalog
EC Number1.3.3.4
HMM Length470
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryHeme, porphyrin, and cobalamin
Gene Ontology TermGO:0004729: oxygen-dependent protoporphyrinogen oxidase activity molecular_function
GO:0006779: porphyrin-containing compound biosynthetic process biological_process
AuthorHaft DH
Entry DateOct 19 1999 4:31PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a precursor of heme and chlorophyll. Bacillus subtilis HemY also has coproporphyrinogen III to coproporphyrin III oxidase activity in a heterologous expression system, although the role for this activity in vivo is unclear. This protein is a flavoprotein and has a beta-alpha-beta dinucleotide binding motif near the amino end.
ReferencesA2 hmmalign AL ClustalW RN [1] RM 96224138 RN [2] RM 95229621 RN [3] RM 99003470
Genome PropertyGenProp0221: protoporphyrin IX biosynthesis from uroporphyrinogen III (HMM)