HMM Summary Page: TIGR00561

FunctionNAD(P)(+) transhydrogenase (AB-specific), alpha subunit
Gene SymbolpntA
Trusted Cutoff444.40
Domain Trusted Cutoff444.40
Noise Cutoff258.60
Domain Noise Cutoff258.60
Isology Typeequivalog
EC Number1.6.1.2
HMM Length511
Mainrole CategoryEnergy metabolism
Subrole CategoryElectron transport
Gene Ontology TermGO:0008750: NAD(P)+ transhydrogenase (AB-specific) activity molecular_function
GO:0055114: oxidation-reduction process biological_process
AuthorHaft DH
Entry DateOct 19 1999 4:31PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis integral membrane protein is the alpha subunit of alpha 2 beta 2 tetramer that couples the proton transport across the membrane to the reversible transfer of hydride ion equivalents between NAD and NADP. An alternate name is pyridine nucleotide transhydrogenase alpha subunit. The N-terminal region is homologous to alanine dehydrogenase. In some species, such as Rhodospirillum rubrum, the alpha chain is replaced by two shorter chains, both with some homology to the full-length alpha chain modeled here. These score below the trusted cutoff.
ReferencesA2 hmmalign DR ECOCYC; EG10744; pntA RM 98358599 RT Site-directed mutagenesis of the proton-pumping pyridine nucleotide transhydrogenase of Escherichia coli. RA Bragg PD RL Biochim Biophys Acta 1998 Jun 10;1365(1-2):98-104 AL clustalw