HMM Summary Page: TIGR00559

Functionpyridoxine 5'-phosphate synthase
Gene SymbolpdxJ
Trusted Cutoff192.75
Domain Trusted Cutoff192.75
Noise Cutoff154.25
Domain Noise Cutoff154.25
Isology Typeequivalog
EC Number2.6.99.2
HMM Length239
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryPyridoxine
Gene Ontology TermGO:0008615: pyridoxine biosynthetic process biological_process
GO:0033856: pyridoxine 5'-phosphate synthase activity molecular_function
AuthorHaft DH
Entry DateOct 19 1999 4:30PM
Last ModifiedFeb 14 2011 3:27PM
CommentPdxJ is required in the biosynthesis of pyridoxine (vitamin B6), a precursor to the enzyme cofactor pyridoxal phosphate. ECOCYC describes the predicted reaction equation as 1-amino-propan-2-one-3-phosphate + deoxyxylulose-5-phosphate = pyridoxine-5'-phosphate. The product of that reaction is oxidized by PdxH to pyridoxal 5'-phosphate.
ReferencesAL clustalw DR SWISS-PROT; P24223; PDXJ_ECOLI; annotation and links to references DR ECOCYC; EG10693; pdxJ; RM 99239931 RT Vitamin B6 biosynthesis: formation of pyridoxine 5'-phosphate from 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose-5-phosphate by PdxA and PdxJ protein. RA Laber B, Maurer W, Scharf S, Stepusin K, Schmidt FS RL FEBS Lett 1999 Apr 16;449(1):45-8 DR HAMAP; MF_00279; 166 of 198
Genome PropertyGenProp0862: pyridoxal phosphate biosynthesis, PdxA/PdxJ pathway (HMM)