HMM Summary Page: TIGR00555

Functionpantothenate kinase
Gene SymbolcoaA
Trusted Cutoff247.60
Domain Trusted Cutoff247.60
Noise Cutoff82.75
Domain Noise Cutoff82.75
Isology Typeequivalog
EC Number2.7.1.33
HMM Length304
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryPantothenate and coenzyme A
Gene Ontology TermGO:0004594: pantothenate kinase activity molecular_function
GO:0006085: acetyl-CoA biosynthetic process biological_process
AuthorHaft DH
Entry DateOct 19 1999 4:30PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model describes a eukaryotic form of pantothenate kinase, characterized from the fungus Aspergillus nidulans and with similar forms known in several other eukaryotes. It also includes forms from several Gram-positive bacteria suggested to have originated from the eukaryotic form by lateral transfer. It differs in a number of biochemical properties (such as inhibition by acetyl-CoA) from most bacterial CoaA and lacks sequence similarity. This enzyme is the key regulatory step in the biosynthesis of coenzyme A (CoA).
ReferencesRN [1] RM 99107849 RT Cloning and characterization of a eukaryotic pantothenate kinase gene (panK) from Aspergillus nidulans. RA Calder RB, Williams RS, Ramaswamy G, Rock CO, Campbell E, Unkles SE, Kinghorn JR, Jackowski S RL Biol Chem 1999 Jan 22;274(4):2014-20 RN [2] RM 12760898 RT Inhibitors of pantothenate kinase: novel antibiotics for staphylococcal infections. RA Choudhry AE, Mandichak TL, Broskey JP, Egolf RW, Kinsland C, Begley TP, Seefeld MA, Ku TW, Brown JR, Zalacain M, Ratnam K. RL Antimicrob Agents Chemother. 2003 Jun; 47(6): 2051-5. DR HAMAP; MF_01273; 19 of 19
Genome PropertyGenProp0171: coenzyme A biosynthesis from pantothenate (HMM)