HMM Summary Page: TIGR00555
| Accession | TIGR00555 |
| Name | panK_eukar |
| Function | pantothenate kinase |
| Gene Symbol | coaA |
| Trusted Cutoff | 247.60 |
| Domain Trusted Cutoff | 247.60 |
| Noise Cutoff | 82.75 |
| Domain Noise Cutoff | 82.75 |
| Isology Type | equivalog |
| EC Number | 2.7.1.33 |
| HMM Length | 304 |
| Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
| Subrole Category | Pantothenate and coenzyme A |
| Gene Ontology Term | GO:0004594: pantothenate kinase activity molecular_function |
| GO:0006085: acetyl-CoA biosynthetic process biological_process | |
| Author | Haft DH |
| Entry Date | Oct 19 1999 4:30PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This model describes a eukaryotic form of pantothenate kinase, characterized from the fungus Aspergillus nidulans and with similar forms known in several other eukaryotes. It also includes forms from several Gram-positive bacteria suggested to have originated from the eukaryotic form by lateral transfer. It differs in a number of biochemical properties (such as inhibition by acetyl-CoA) from most bacterial CoaA and lacks sequence similarity. This enzyme is the key regulatory step in the biosynthesis of coenzyme A (CoA). |
| References | RN [1] RM 99107849 RT Cloning and characterization of a eukaryotic pantothenate kinase gene (panK) from Aspergillus nidulans. RA Calder RB, Williams RS, Ramaswamy G, Rock CO, Campbell E, Unkles SE, Kinghorn JR, Jackowski S RL Biol Chem 1999 Jan 22;274(4):2014-20 RN [2] RM 12760898 RT Inhibitors of pantothenate kinase: novel antibiotics for staphylococcal infections. RA Choudhry AE, Mandichak TL, Broskey JP, Egolf RW, Kinsland C, Begley TP, Seefeld MA, Ku TW, Brown JR, Zalacain M, Ratnam K. RL Antimicrob Agents Chemother. 2003 Jun; 47(6): 2051-5. DR HAMAP; MF_01273; 19 of 19 |
| Genome Property | GenProp0171: coenzyme A biosynthesis from pantothenate (HMM) |