HMM Summary Page: TIGR00554

Functionpantothenate kinase
Gene SymbolcoaA
Trusted Cutoff306.20
Domain Trusted Cutoff306.20
Noise Cutoff185.70
Domain Noise Cutoff185.70
Isology Typeequivalog
EC Number2.7.1.33
HMM Length307
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryPantothenate and coenzyme A
Gene Ontology TermGO:0004594: pantothenate kinase activity molecular_function
GO:0015937: coenzyme A biosynthetic process biological_process
AuthorHaft DH
Entry DateOct 19 1999 4:30PM
Last ModifiedFeb 14 2011 3:27PM
CommentShown to be a homodimer in E. coli. This enzyme catalyzes the rate-limiting step in the biosynthesis of coenzyme A. It is very well conserved from E. coli to B. subtilis, but differs considerably from known eukaryotic forms, described in a separate model.
ReferencesRM 95014575 RT Kinetics and regulation of pantothenate kinase from Escherichia coli. RA Song WJ, Jackowski S RL J Biol Chem 1994 Oct 28;269(43):27051-8 DR HAMAP; MF_00215; 158 of 161
Genome PropertyGenProp0171: coenzyme A biosynthesis from pantothenate (HMM)