HMM Summary Page: TIGR00553

Functionaminodeoxychorismate synthase, component I
Gene SymbolpabB
Trusted Cutoff328.40
Domain Trusted Cutoff328.40
Noise Cutoff327.20
Domain Noise Cutoff327.20
Isology Typeequivalog
EC Number2.6.1.85
HMM Length329
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryFolic acid
Gene Ontology TermGO:0008153: para-aminobenzoic acid biosynthetic process biological_process
GO:0009396: folic acid-containing compound biosynthetic process biological_process
GO:0046820: 4-amino-4-deoxychorismate synthase activity molecular_function
AuthorSelengut J, Haft DH
Entry DateOct 19 1999 4:30PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family, aminodeoxychorismate synthase, component I (PabB), were designated para-aminobenzoate synthase component I until it was recognized that PabC, a lyase, completes the pathway of PABA synthesis. This family is closely related to anthranilate synthase component I (trpE), and both act on chorismate. The clade of PabB enzymes represented by this model includes sequences from Gram-positive and alpha and gamma Proteobacteria as well as Chlorobium, Nostoc, Fusobacterium and Arabidopsis. A closely related clade of fungal PabB enzymes is identified by TIGR01823, while another bacterial clade of potential PabB enzymes is more closely related to TrpE (TIGR01824).
ReferencesA2 hmmalign DR ECOCYC; EG10683; pabB;
Genome PropertyGenProp0759: para-aminobenzoic acid (PABA) biosynthesis from chorismate (HMM)