Accession | TIGR00552 |
Name | nadE |
Function | NAD+ synthetase |
Gene Symbol | nadE |
Trusted Cutoff | 63.65 |
Domain Trusted Cutoff | 63.65 |
Noise Cutoff | 57.50 |
Domain Noise Cutoff | 57.50 |
Isology Type | equivalog_domain |
EC Number | 6.3.1.5 |
HMM Length | 251 |
Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
Subrole Category | Pyridine nucleotides |
Gene Ontology Term | GO:0005737: cytoplasm cellular_component |
| GO:0008795: NAD+ synthase activity molecular_function |
| GO:0009435: NAD biosynthetic process biological_process |
Author | Haft DH |
Entry Date | Oct 19 1999 4:30PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | NAD+ synthetase is a nearly ubiquitous enzyme for the final step in the biosynthesis of the essensial cofactor NAD. The member of this family from Bacillus subtilis is a strictly NH(3)-dependent NAD(+) synthetase of 272 amino acids. Proteins consisting only of the domain modeled here may be named as NH3-dependent NAD+ synthetase. Amidotransferase activity may reside in a separate protein, or not be present. Some other members of the family, such as from Mycobacterium tuberculosis, are considerably longer, contain an apparent amidotransferase domain, and show glutamine-dependent as well as NH(3)-dependent activity. |
References | AL clustalw
RM 98292757
RT The MTCY428.08 gene of Mycobacterium tuberculosis codes for NAD+ synthetase.
RA Cantoni R, Branzoni M, Labo M, Rizzi M, Riccardi G
RL J Bacteriol 1998 Jun;180(12):3218-21
DR HAMAP; MF_00193; 189 of 191 |
Genome Property | GenProp0057: NAD(P) biosynthesis from L-aspartate and DHAP (HMM) |