HMM Summary Page: TIGR00551

FunctionL-aspartate oxidase
Gene SymbolnadB
Trusted Cutoff452.75
Domain Trusted Cutoff452.75
Noise Cutoff425.60
Domain Noise Cutoff425.60
Isology Typeequivalog
EC Number1.4.3.16
HMM Length489
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryPyridine nucleotides
Gene Ontology TermGO:0008734: L-aspartate oxidase activity molecular_function
GO:0019363: pyridine nucleotide biosynthetic process biological_process
GO:0019804: quinolinate synthetase complex cellular_component
AuthorHaft DH
Entry DateOct 19 1999 4:30PM
Last ModifiedFeb 14 2011 3:27PM
CommentL-aspartate oxidase is the B protein, NadB, of the quinolinate synthetase complex. Quinolinate synthetase makes a precursor of the pyridine nucleotide portion of NAD. This model identifies proteins that cluster as L-aspartate oxidase (a flavoprotein difficult to separate from the set of closely related flavoprotein subunits of succinate dehydrogenase and fumarate reductase) by both UPGMA and neighbor-joining trees. The most distant protein accepted as an L-aspartate oxidase (NadB), that from Pyrococcus horikoshii, not only clusters with other NadB but is just one gene away from NadA.
ReferencesA2 hmmalign DR PFAM; PF00890; FAD_binding_2
Genome PropertyGenProp0057: NAD(P) biosynthesis from L-aspartate and DHAP (HMM)