| Accession | TIGR00550 |
| Name | nadA |
| Function | quinolinate synthetase complex, A subunit |
| Gene Symbol | nadA |
| Trusted Cutoff | 262.90 |
| Domain Trusted Cutoff | 262.90 |
| Noise Cutoff | 106.85 |
| Domain Noise Cutoff | 106.85 |
| Isology Type | equivalog |
| EC Number | 2.5.1.72 |
| HMM Length | 309 |
| Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
| Subrole Category | Pyridine nucleotides |
| Gene Ontology Term | GO:0008987: quinolinate synthetase A activity molecular_function |
| | GO:0019363: pyridine nucleotide biosynthetic process biological_process |
| | GO:0019804: quinolinate synthetase complex cellular_component |
| Author | Haft DH, Anolik RT |
| Entry Date | Oct 19 1999 4:30PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This protein, termed NadA, plays a role in the synthesis of pyridine, a precursor to NAD. The quinolinate synthetase complex consists of A protein (this protein) and B protein. B protein converts L-aspartate to iminoaspartate, an unstable reaction product which in the absence of A protein is spontaneously hydrolyzed to form oxaloacetate. The A protein, NadA, converts iminoaspartate to quinolate. |
| References | GA hmmsearch
DR ECOCYC; EG10630; nadA;
AL clustalw
DR HAMAP; MF_00569; 27 of 27 |
| Genome Property | GenProp0057: NAD(P) biosynthesis from L-aspartate and DHAP (HMM) |
