HMM Summary Page: TIGR00549

Functionmevalonate kinase
Gene Symbolmvk
Trusted Cutoff163.05
Domain Trusted Cutoff163.05
Noise Cutoff139.40
Domain Noise Cutoff139.40
Isology Typeequivalog
EC Number2.7.1.36
HMM Length276
Mainrole CategoryCentral intermediary metabolism
Subrole CategoryOther
Gene Ontology TermGO:0004496: mevalonate kinase activity molecular_function
GO:0016126: sterol biosynthetic process biological_process
GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway biological_process
AuthorSelengut J, Haft DH
Entry DateOct 19 1999 4:30PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis [1]. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped [2].
ReferencesRN [1] RM PMID: 10497066 RT Overexpression, purification, and characterization of the thermostable mevalonate kinase from Methanococcus jannaschii. RA Huang KX, Scott AI, Bennett GN. RL Protein Expr Purif. 1999 Oct;17(1):33-40. RN [2] RM PMID: 12384294 RT Genetics of isoprenoid biosynthesis in Paracoccus zeaxanthinifaciens. RA Humbelin M, Thomas A, Lin J, Li J, Jore J, Berry A. RL Gene. 2002 Sep 4;297(1-2):129-39. AL Clustalw DR HAMAP; MF_00217; 8 of 8
Genome PropertyGenProp0047: IPP biosynthesis via mevalonate (HMM)