| Accession | TIGR00549 |
| Name | mevalon_kin |
| Function | mevalonate kinase |
| Gene Symbol | mvk |
| Trusted Cutoff | 163.05 |
| Domain Trusted Cutoff | 163.05 |
| Noise Cutoff | 139.40 |
| Domain Noise Cutoff | 139.40 |
| Isology Type | equivalog |
| EC Number | 2.7.1.36 |
| HMM Length | 276 |
| Mainrole Category | Central intermediary metabolism |
| Subrole Category | Other |
| Gene Ontology Term | GO:0004496: mevalonate kinase activity molecular_function |
| | GO:0016126: sterol biosynthetic process biological_process |
| | GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway biological_process |
| Author | Selengut J, Haft DH |
| Entry Date | Oct 19 1999 4:30PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis [1]. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria.
The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade.
Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped [2]. |
| References | RN [1]
RM PMID: 10497066
RT Overexpression, purification, and characterization of the thermostable mevalonate kinase from Methanococcus jannaschii.
RA Huang KX, Scott AI, Bennett GN.
RL Protein Expr Purif. 1999 Oct;17(1):33-40.
RN [2]
RM PMID: 12384294
RT Genetics of isoprenoid biosynthesis in Paracoccus zeaxanthinifaciens.
RA Humbelin M, Thomas A, Lin J, Li J, Jore J, Berry A.
RL Gene. 2002 Sep 4;297(1-2):129-39.
AL Clustalw
DR HAMAP; MF_00217; 8 of 8 |
| Genome Property | GenProp0047: IPP biosynthesis via mevalonate (HMM) |
