HMM Summary Page: TIGR00547

Functionouter membrane lipoprotein carrier protein LolA
Gene SymbollolA
Trusted Cutoff48.60
Domain Trusted Cutoff48.60
Noise Cutoff33.95
Domain Noise Cutoff33.95
Isology Typeequivalog
HMM Length204
Mainrole CategoryProtein fate
Subrole CategoryProtein and peptide secretion and trafficking
Gene Ontology TermGO:0008320: protein transmembrane transporter activity molecular_function
GO:0009306: protein secretion biological_process
AuthorHaft DH
Entry DateOct 19 1999 4:30PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis protein, LolA, is known so far only in the gamma and beta subdivisions of the Proteobacteria. The E. coli major outer lipoprotein (Lpp) of E. coli is released from the inner membrane as a complex with this chaperone in an energy-requiring process, and is then delivered to LolB for insertion into the outer membrane. LolA is involved in the delivery of lipoproteins generally, rather than just Lpp, and is an essential protein in E. coli, unlike Lpp itself.
ReferencesAL ClustalW RN [1] RM 99047631 RT LolA-dependent release of a lipid-modified protein from the inner membrane of Escherichia coli requires nucleoside triphosphate. RA Yakushi T, Yokota N, Matsuyama S, Tokuda H RL J Biol Chem 1998 Dec 4;273(49):32576-81 RN [2] RM 99065127 RT Genetic analyses of the in vivo function of LolA, a periplasmic chaperone involved in the outer membrane localization of Escherichia coli lipoproteins. RA Tajima T, Yokota N, Matsuyama S, Tokuda H RL FEBS Lett 1998 Nov 13;439(1-2):51-4 DR HAMAP; MF_00240; 122 of 131
Genome PropertyGenProp0207: lipoprotein localization system lolABCDE (HMM)