HMM Summary Page: TIGR00545

Functionlipoyltransferase and lipoate-protein ligase
Trusted Cutoff201.85
Domain Trusted Cutoff201.85
Noise Cutoff117.10
Domain Noise Cutoff117.10
Isology Typesubfamily
HMM Length326
Mainrole CategoryProtein fate
Subrole CategoryProtein modification and repair
Gene Ontology TermGO:0006464: protein modification process biological_process
GO:0017118: lipoyltransferase activity molecular_function
AuthorHaft DH
Entry DateOct 19 1999 4:30PM
Last ModifiedFeb 14 2011 3:27PM
CommentOne member of this group of proteins is bovine lipoyltransferase, which transfers the lipoyl group from lipoyl-AMP to the specific Lys of lipoate-dependent enzymes. However, it does not first activate lipoic acid with ATP to create lipoyl-AMP and pyrophosphate. Another member of this group, lipoate-protein ligase A from E. coli, catalyzes both the activation and the transfer of lipoate. Homology between the two is full-length, except for the bovine mitochondrial targeting signal, but is strongest toward the N-terminus.
ReferencesAL ClustalW_manual RM 98070355 RT Cloning and expression of a cDNA encoding bovine lipoyltransferase. RA Fujiwara K, Okamura-Ikeda K, Motokawa Y RL J Biol Chem 1997 Dec 19;272(51):31974-8 DR HAMAP; MF_01602; 37 of 38